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Redressing Chanel "A bunch of old clothes in a basement doesn t interest Moncler Men Black Red White 90% Of Wool Sweater us," Chanel head designer Lagerfeld sniffed, by "us" meaning himself and Clickkeyword[Alain+Wertheimer]" >Alain Wertheimer, chairman of Chanel, both of whom had plenty to say about the content of the exhibit, since their company was paying for the lion s share of it. de Montebello has booted Karl and his vision out the door bad he didn t do the same to Clickkeyword[Tommy+Hilfiger+Corporation]" >Tommy Hilfiger and that rock and roll fashion fiasco last year should be done to properly honor the sacred monster Chanel? A few modest proposals:1. The Met could build a series of dioramas, highlighting dramatic developments in the life of the designer. The first would contain a Chanel mannequin in a little black dress, conversing with belle epoque designer Clickkeyword[Paul+Poiret]" >Paul Poiret. The Poiret figure would be surrounded by mannequins dressed in lavish Poiret creations: a symphony of brocade bat wing sleeves, Moncler Men Vest velvet cocoon coats, hobble skirts, embroidered turbans, and other lush finery, in contrast to Chanel s plain dark dress, unadorned straw boater, and flat shoes. (An accompanying showcase would hold row upon row of the torturous Victorian underwear that both Poiret and Chanel had a hand in banishing.) A wall placard explaining the scene would retell a famous conversation between the designers that took place when the two met on a Paris street around 80 years ago: "Who are you in mourning for, Mademoiselle Chanel?" asked Poiret, surveying Chanel s austere ensemble. "For you, monsieur," she replied.2. The second tableau might show a Coco Chanel mannequin with a furious look on its face, dressed in a little black suit with a cardigan jacket and a triple length rope of pearls (fake), just like the ones the designer was reportedly sporting when she was denied access to her own premises by striking seamstresses and saleswomen (the vendeuses in chic black dresses, the seamstresses in smocks) in June 1936. An accompanying showcase could display a ribbon tied cardboard coffer, a reproduction of the traditional strikers collection box, with a slotted top for contributions from passersby, and an "Occupied" sign, both of which hung on the maison s porte cochere the day the Chanel workers went on strike. (Chanel responded by firing 300 people but eventually was forced to settle.) A wall placard could quote what a still boiling Chanel told a journalist decades later: "A sit down strike. Graceful, wouldn t you say? Attractive to think of women in such a position, on their behinds. I mean, what idiots those girls were!"3. Instead of the famous curving Rue Cambon stairway that de Montebello planned to replicate at the Met show, why not reproduce Chanel s room at the Clickkeyword[The+Ritz Carlton+Hotel+Co.+LLC]" >Paris Ritz, where she lived openly with her lover, Nazi officer Clickkeyword[Hans+Gunther+von+Dincklage]" >Hans Gunther von Dincklage, during World War II? The Chanel mannequin, dressed in a little black kimono, might be sipping an espresso and reading Signal, the Anglophobic, anti Semitic daily newspaper of the period that had a circulation of 420,000. (Budget permitting, an accompanying von Dincklage doll could be dressed in a stylish green Nazi uniform.) A wall placard could tell visitors Coco s response when she was asked why she had consorted with a German: "Really, sir, a woman of my age cannot be expected to look at his passport if she has a chance of a lover."4. A diorama of Chanel s workshop, circa 1954, late at night before her first fashion show since the war. (After years of exile in Clickkeyword[Switzerland]" >Switzerland, she d decided it was safe to come back to Paris.) The mannequin would have a tiny, wizened face: Madame was well on in years when she resumed pinning and pining. A pair of scissors would dangle from a ribbon around the dummy s neck, complementing the rest of the ensemble: tweed suit with double C buttons, black and beige sling back shoes, quilted chain strapped handbag, etc. A case nearby could show off fake Chanel Moncler Badia Very Shiny Women's Down Jackets Black T shirts, fake Chanel watches, and fake Chanel purses, all purchased on Canal Street, and the wall card might offer a quote from the designer, who late in her life was fond of issuing bons mots to the press: "Fashion does not exist unless it goes down into the streets. The fashion that remains in the salons has no more significance than a costume ball."

Moncler Girls Vest

Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid In the reward circuitry of the brain, acetylcholine receptors ( modulate effects of (THC), marijuana main psychoactive ingredient. Kynurenic acid (KYNA) is an endogenous negative allosteric modulator of Here we report that the kynurenine 3 monooxygenase (KMO) inhibitor Ro 61 8048 increases brain KYNA levels and attenuates cannabinoid induced increases in extracellular dopamine in reward related brain areas. In the self administration model of drug abuse, Ro 61 8048 reduced the rewarding effects of THC and the synthetic cannabinoid WIN 55,212 2 in squirrel monkeys and rats, respectively, Moncler Trench Coat and it also prevented relapse to drug seeking induced by reexposure to cannabinoids or cannabinoid associated cues. The effects of enhancing endogenous KYNA levels with Ro 61 8048 were prevented by positive allosteric modulators of Despite a clear need, there are no medications approved for treatment of marijuana dependence. Modulation of KYNA offers a pharmacological strategy for achieving abstinence from marijuana and preventing relapse. Figure 2: Effects of elevated brain KYNA on THC induced elevations of extracellular dopamine (that is, dopamine overflow) in NAc shell and VTA of freely moving rats. (a THC (3 mg per kg) increased dopamine as compared to basal levels in both NAc shell (a; average basal concentrations, 37.60 2.70 fmol per 10 n = 7 rats) and VTA (c; average basal concentration, 26.18 3.80 fmol per 10 n = 7). The effects of THC on dopamine in NAc shell (a,b) were significantly attenuated by pretreatment with 100 mg per kg Ro 61 8048 (Ro; n = 6), and the effects of THC on dopamine in VTA (c,d) were significantly attenuated by pretreatment with 30 (n = 5) or 100 mg per kg Ro 61 8048 (n = 6). Ro 61 8048 alone (both n = 5) did not affect extracellular levels of dopamine in either area. (e,f) Local infusion of KYNA (500 nM) (n = 5) into NAc shell significantly reduced THC induced dopamine elevations in NAc shell (e,f; n = 5). Arrows indicate time of THC, Ro 61 8048 or vehicle injection or local infusion of KYNA. Data are presented over the course of the session as a percentage of basal values (a,c,e) or as AUC during the first 120 min after THC or vehicle injection, expressed as a percentage of the mean value in the vehicle + THC group (b,d,f). 0.05 versus baseline, 0.05 versus vehicle + THC. Dosages are given in mg per kg; Veh, vehicle. The Ro 61 8048 vehicle was given 40 min before each baseline session. (g Number of THC injections per Moncler Sale Mens session (g), overall response rates in the presence of the green light signaling THC availability (h) and total THC intake per session (i) as a function of the THC dose. of the last three sessions under each THC condition and under vehicle conditions (n = 3 monkeys). Pretreatment with Ro 61 8048 (20 mg per kg) caused a rightward shift of the THC dose response curves compared to vehicle pretreatment. represents THC vehicle. Both doses of THC significantly decreased accuracy (b; P 0.007), but this was not exacerbated by Ro 61 8048 (c,d). (e,f) The 20 mg per kg dose of Ro 61 8048, which was effective in blocking the effects of THC in reward related brain areas in monkeys, did not have deleterious effects on short term memory in monkeys when given alone (e) or in combination with THC (f) in a delayed matching to sample model of working memory. Dosages are given in mg per kg. The percentage of responses on the CB1 agonist lever was a monotonically increasing function of dose. Abscissae, dose, log scale; ordinate, percentage of responses on the THC associated lever (a) or response rate (b). with various doses of THC, the percentage of responses on the CB1 appropriate lever was a monotonically increasing function of cumulative dose (c). Ro 61 8048 did not significantly affect response rates after THC administration in this procedure (d). Abscissae, cumulative THC dose, log scale; ordinate, percentage of responses on the AM4054 associated lever (c) or response rate (d). Symbols left of the abscissa breaks indicate performance during vehicle and AM4054 control sessions. (n = 9 rats, n = 3 monkeys). The number of food pellets per session (a) and overall response rates in the presence of the green light signaling food availability (b) are shown. was involved in the design of the study, supervised and analyzed the primate self administration and reinstatement experiments and rodent drug discrimination experiments, and wrote the first draft of the manuscript. was involved in design of the study, conducted microdialysis experiments including collection of all samples, performed dopamine assay, analyzed microdialysis data and helped prepare the final draft of the manuscript. analyzed KYNA levels in microdialysis samples. conducted and analyzed microdialysis experiments with local KYNA infusion and PNU120596. conducted the primate self administration and reinstatement Moncler Quality experiments. conducted rodent drug discrimination experiments and was involved in discussions of the data. conducted the rat self administration and microdialysis experiments with WIN 55,212 2. M. Scherma supervised the rat self administration and microdialysis experiments with WIN 55,212 2, analyzed the data and was involved in the discussions of the data. was involved in the discussions of the data. assisted in conducting the microdialysis experiments with THC. designed, conducted and analyzed the data from the primate discrimination and memory experiments. were involved in the design of the study and discussions of the data. conceived, designed and supervised the study and edited the manuscript. Supplementary Figure 1: Ro 61 8048 reverses the depressant effects of THC on food self administration in monkeys. The number of food pellets per session (a) and overall response rates in the presence of the green light signaling food availability (b) are shown. vehicle + THC 0.56 condition, Bonferroni test. The number of food pellets per session (a) and overall response rates in the presence of the green light signaling food availability (b) are shown. vehicle + THC 0.56 condition, Bonferroni test.

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