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including receipts from his online ammunition purchases and unseen Youtube videos An interesting aside to this story is his mention that he fathered a baby to Lee Ann Valdiserri. That led me to do some digging on this Lee Ann. Turns out that Lee Add Valdiserri of South Park, PA died in 2004 at the age of 41. 5 years ago would have put her at 46 if she were still alive today. He is married to Tina Valdiserri, who is Lee Ann sister. Lee Ann had two kids, Gary Jr. and Daniel. Gary Jr. was born in 1990. In Sodini blog, he said he fathered a child to Lee Ann in early 1991. So the speculation is that it could be possible that Sodini could have fathered Gary Jr. You can see Gary Jr. Lee Ann died in 2004 of "respiratory failure" which is most likely drug/alcohol related. Then both her nephew "Mario" died of going to fast and wrecking his car into a telephone pole and her niece "Noelle" apparently died from a boyfriend throwing her down a flight of stairs. VALDISERRI LEE ANN On Sunday, October 31, 2004, Lee Ann, 41, of South Park; beloved wife of Gary Musial; mother of Gary Lee and Daniel Patrick Musial; daughter of Paul and Myrna Valdiserri; sister of Paul, Victoria and Tina. Friends received Tuesday 2 4 7 9 pm at the GRIFFITH MORTUARY, INC. 5636 Brownsville Road, Broughton Curry South Park Twp. where a Blessing Moncler S Service will be held on Wednesday at 11 am. VALDISERRI NOELLE M. On Saturday, September 13, 2008, Noelle, 28, of Jefferson Hills; Beloved daughter of Paul B. and Nancy C. (Malenka) Valdiserri of South Park Twp.; sister of Paul C. Valdiserri and the late Mario T. Valdiserri; Granddaughter of Paul D. and Myrna Valdiserri of Arizona; Niece of Victoria (Tom) McGrath, Tina (Leo) Gabryelski, Mindy Savatt, Michael (Lori) Malenka and the late Lee Moncler Women Down Jackets Ox Horn Buckle Collar Black Ann Valdiserri; Goddaughter of Thomas (Joanne) Rostek. Services and Interment private. Valdiserri, 19, of South Park and Jefferson Hills, died Thursday, Sept. 21, 2006. Mario was a graduate of Thomas Jefferson High School and Steel Valley Technical School. Beloved son of Paul B. and Nancy C. (Malenka) Valdiserri, of South Park. Brother of Paul C. and Noelle M. Valdiserri. Grandson of Paul D. and Myrna Valdiserri, of Arizona. Nephew of Victoria (Tom) McGrath, Tina (Leo) Gabryilski and the late Lee Ann Valdiserri. Sunday at the GRIFFITH MORTUARY INC., 5636 Brownsville Road, South Park. Monday in the funeral home, followed by Mass of Christian Burial at 10 in Nativity Church. Interment private. There is clear psychopathology in these works. He was clearly in need of psychiatric assistance and, possibly, antipsychotic medications. However, there does not appear to be clear evidence of sociopathology, but perhaps there was some evidence on his "security" page. He appears to be fairly functional. The pathology appears to stems from a perceived traumatic history beginning in childhood. Patient complains of repeated mental insult and harm from family members. Behavioral pattern began in childhood. Pt repeatedly refers to a lack of control over functional and social aspects of his life. Complains of personal change that was perceived to lead to benefit, Moncler Men Coats Givorse For Black Collar With Buttons but did not. Complains of inability to successfully initiate relationships with sexually desirable members of opposite gender. Depressive symptoms include suicidal and homicidal ideations. There appear to be plans to realize these ideations. Religious and personal introspections are consistent with end of life planning. I noticed there are not many commenting on pastor Knapp of the Tetelestai church. The pastor who trained Knapp had a huge following at Berachah Church in Texas. He name was Robert Bunger Thieme, Jr., he is retired now but passed the torch on to his son R Thieme III. The former pastor was an extreme Fundamentalist and very controlling. he made other fundamentalist, with the exception of maybe Hyles/Anderson, look like little choir boys. There are support groups and people in therapy who came out of the teachings of Thieme camp. Thieme was also a commissioned Lieutenant Colonel. Sometimes he would preach in his uniform, people would just call him "the Colonel". He was very militant. Sodini hated his former pastor and church, BTW Thieme ordained pastor Knapp back in 1991. Lots of kids who grew up and came out of those churches were forced to listen at home to hours and hours of the taped teachings. Like I said, many are in therapy and support groups. close this windowyou ll need to login or register to do thatcreate a new accountall it takes is a username and password.

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a therapeutic agent for APL Over the past 5 years, it has been well demonstrated that As2O3 induces a high complete remission (CR) rate in both primary and relapsed APL patients (around 85 The side effects are mild to moderate in relapsed patients, while severe hepatic lesions have been found in some primary cases. After CR obtained in relapsed patients, chemotherapy in combination with As2O3 as post remission therapy has given better survival than those treated with As2O3 alone. Cell biology studies have revealed that As2O3 exerts dose dependent dual effects on APL cells. Apoptosis is evident when cells are treated with 0.5 M of As2O3 while partial differentiation is observed using low concentrations (0.1 M) of the drug. The apoptosis inducing effect is associated with the collapse of mitochondrial transmembrane potentials in a thiol dependent manner, whereas the mechanisms underlying APL cell differentiation induced by low dose arsenic remain to be explored. Paradoxically, arsenic has also long been demonstrated to have anti cancer activity in some cases. In traditional Chinese medicine, arsenic trioxide (As2O3) was recorded in the Compendium of Materia Medica by Mr Li Shi Zhen (1518 In Western medicine, arsenous oxide (Fowler s solution) was used as a treatment of choice for chronic myeloid leukemia (CML) in the 19th century. As Osler stated in his 1892 textbook of medicine, There are certain remedies that have an influence upon the disease. Of these, arsenic, given in large doses, is the best. I have repeatedly seen improvement under its use. However, due to toxic side effects of long term heroic dose of oral arsenic in most patients, and with the advent of modern radiotherapy and chemotherapy, the arsenic treatment for CML was given up in Western medicine (Kwong and Todd 1997; Tamm et al., 1998). Recently, a discovery on the therapeutic effect of As2O3 in acute promyelocytic leukemia (APL) has revived this ancient drug (Chen et al., 1996; Mervis, 1996; Look, 1998; Gallagher, 1998; Conrad, 1999; Warrell, 1999; Slack and Rusiniak, 2000; Wang and Chen, 2000; Chen et al., 2001). Over the past several years, As2O3 as an effective salvage treatment for relapsed and/or refractory APL patients has been confirmed Moncler Bicester worldwide. Recently, this drug was formally approved by the State Drug Administration (SDA) in China (1999) and the Food and Drug Administration (FDA) of the United States of America (Cohen et al., 2001). Encouraged by such a bedside discovery, mechanisms of action of As2O3 have been actively addressed by many groups. The potentials of As2O3 in the treatment of cancers other than APL are also under exploration. Here, we shall discuss the recent advances in the clinical practices and the mechanisms of action of As2O3 in APL. Clinical practice of As2O3 in the treatment of APLThe recent clinical trial of As2O3 was started in 1971. A group from the First Hospital affiliated with the Harbin Medical University, China, used this compound through intravenous administration in more than 1000 cases of different types of cancer. Therapeutic effects were observed in several cancer types, including CML, lymphoma, esophageal cancer, and particularly APL. The preliminary result in APL was reported in 1992 (Sun et al., 1992). A preparation containing arsenic with a trace amount of mercury chloride was administered at a dose of 10 mg As2O3/day and could induce clinical complete remission (CR) in 21 out of 32 (65.6%) patients without major toxic side effects. In 1996, two reports were made from China using purified As2O3 (0.16 mg/kg/day). The Harbin group (Zhang et al., 1996) showed that As2O3 treatment achieved CR in 52.4% (22/42) relapsed APL patients. The Shanghai Institute of Hematology (SIH) reported an even better result among 15 patients relapsed after ATRA and chemotherapy, with CR achieved in nine of 10 patients treated with As2O3 alone and five of five patients treated with As2O3/chemotherapy combination. The treatment duration for induction of remission was 28 days. The pharmacokinetic studies were performed among eight relapsed patients by measuring plasma drug levels with gas chromatography. The results showed that after a peak level of 6.85 (5.54 mol/L, plasma arsenic was rapidly eliminated, with a t1/2 of 0.89 (SD: 0.29) h and a t1/2 of 12.13 (SD: 3.31) h. Hence, over most times during As2O3 treatment, plasma arsenic levels fluctuated between 0.1 M. Such a pharmacokinetic behavior did not alter after continuous use of As2O3. Increased amounts of arsenic appeared in the urine with a daily excretion accounting for approximately 1 of the total daily dose used. Arsenic contents in hair and nails were increased during treatment and declined after withdrawal of the drug (Chen et al., 1996; Shen et al., 1997). The Memorial Sloan Kettering Cancer Center of New York was the first to use As2O3 in the treatment of APL patients in Western countries. In the first report (Soignet et al., 1998), eleven of the 12 patients had a CR after treatment with 0.06 mg As2O3/kg/day for 12 days. multicenter study performed in 40 patients achieved a CR rate of 85% (Cohen et al., 2001). In addition, the effectiveness of As2O3 in the treatment of APL was also reported by some small scale studies (Huang et al., 1998; Agis et al., 1999; Galimberti et al., 1999; Ohnishi et al., 2000; Zhang et al., 2000; Lin et al., 2000a). Recently, a trial using low dose As2O3 (0.08 mg/kg/day) was carried out in SIH (Shen et al., 2001). Among 20 cases studied, a similar CR rate (80%) was achieved as compared to that attained with a conventional dose. Pharmacokinetic study was conducted in six patients given low dose As2O3. The mean Cpmax was 2.63 (range, 1.54 mol/L, nearly half of the levels with a standard dose, and the ranges of t1/2 and t1/2 were 1.2 h and 6.23 h, respectively. Of note, the arsenic concentrations in the plasma of bone marrow (BM) in five patients 24 h after administration of the drug at low dose were 0.061 mol/L. Improvement of bleeding diathesis with As2O3 treatment Clinically, in patients with APL, the Moncler Online Retailers disease is frequently accompanied by a bleeding syndrome, which is often exacerbated by chemotherapy and causes death at the early stage of treatment. It was suggested that the aberrant expression of tissue factor (TF) in APL cells is at least one of the mechanisms underlying the pathogenesis of the APL coagulopathy (Barbui et al., 1998; Cheng et al., 1999; Tallman, 1999). In APL patients receiving As2O3 treatment, the improvement of disseminated intravascular coagulation (DIC) or hyperfibrinolysis paralleled the amelioration of bleeding symptoms, the correction of plasma fibrinogen level, and the decrease in membrane procoagulant activity (PCA) as well as TF contents of APL blasts (Zhu et al., 1999; Agis et al., 1999). Consistent with the in vivo findings, the membrane PCA and TF at both protein and mRNA levels in APL cell line NB4 were rapidly down regulated by 1 M As2O3 (Zhu et al., 1999; Ohsawa et al., 2000). During As2O3 treatment in APL patients, there exists no BM depression. Instead, As2O3 induces leukocytosis in about 50% of patients (Shen et al., 1997; Soignet et al., 1998, Niu et al., 1999; Camacho et al., 2000). These patients can even develop retinoic Moncler Made In acid syndrome (RAS) like symptoms such as fever, skin rash, edema, which were quickly relieved by steroid administration (Lin et al., 2000b). The leukocytosis could resolve in all cases without chemotherapy (Camacho et al., 2000). Other mild side effects were encountered in about 40 of relapsed patients, such as fatigue, fever, edema, nausea, anorexia, diarrhea, emesis, headache, insomnia, cough, dyspnea, dermatitis, tachycardia, pain, hypokalemia, hypomagnesemia, and hyperglycemia. The most common (>10%) Grade 3 or 4 adverse events were abdominal pain, epistaxis, dyspnea, hypoxia, bone pain, thrombocytopenia, neutropenia, hypokalemia, and hyperglycemia (Shen et al., 1997; Soignet et al., 1998; Cohen et al., 2001). Of note, evident polyneuropathy compatible with chronic arsenic toxicity was noted in a few patients who received As2O3 maintenance therapy and one even had marked distal muscular atrophy (Huang et al., 1998). Cardiac dysrhythmias were reported with arsenic use (Huang et al., 1999). In a recent report from Japan, prolonged QT intervals were observed in all patients during induction therapy with As2O3 and ventricular premature contractions were noticed during eight of 12 courses of therapy (Ohnishi et al., 2000). QT prolongation was also seen in 16 (38%) patients in the study from FDA (Cohen et al., 2001), which could return to baseline following cessation of As2O3. In a recent clinical study conducted in SIH (Niu et al., 1999), 11 newly diagnosed APL patients received As2O3 treatment with informed consent. The CR was obtained in eight (72.7%) of them. However, As2O3 treatment resulted in elevated plasma liver transaminase levels in seven cases and two died of severe hepatic toxicity, in contrast to the mild liver dysfunction in about one third of the patients treated for relapsed APL. Three groups were formed, including four cases treated with chemotherapy alone (group A), 18 with As2O3 alone (group B) and 11 with both As2O3 and chemotherapy (group C). Although the estimated disease free survival (DSF) rates at 1 and 2 years in all patients were 63.6% and 41.6%, respectively, recurrence of leukemia developed in 3/4 cases in group A, 12/18 in group B and 2/11 in group C. Combining chemotherapy and As2O3 seems able to decrease the relapse and to yield a statistically significant better survival status compared to arsenic alone as post remission treatment (Niu et al., 1999). Recent data showed that the estimated 2 year DFS (49.1%) was not different in the low dose As2O3 treatment group as compared with that of the standard dose (Shen et al., 2001). RT analysis in both newly diagnosed and relapsed groups showed that application of As2O3 for a short period of time was not sufficient to eliminate minimal residual disease. Long term use of the drug could, nevertheless, lead to a molecular remission at least in some patients (Niu et al., 1999). Of five patients reported by Zhang et al. Dual activities of As2O3 on APL cells in vivo and in vitro: induction of apoptosis and differentiation The clinical effectiveness of As2O3 in APL has stimulated research activities aiming at an understanding of its mechanisms of action. Although many questions remain to be understood, in vivo and in vitro data suggested that induction of apoptosis and partial differentiation of APL cells is likely to constitute the cellular basis of the effects of As2O3 (Figure 1). Initial clinical observations showed that during daily continuous intravenous infusion of As2O3 in APL, a large amount of myelocyte like cells and degenerative, dying cells with condensed nuclei losing cytoplasm appeared in both BM and peripheral blood, with the gradual reduction of leukemic promyelocytes. Those degenerative cells were positively labeled by in situ terminal deoxynucleotidyl transferase, which is characteristic of programmed cell death (Chen et al., 1997). The presence of leukocytosis and RAS like syndrome during arsenic treatment also supports the idea that As2O3 could induce differentiation. A similar finding was described by Huang et al. (1998). Soignet et al. (1998) performed a further in vivo analysis on the mechanisms of action of As2O3. They reported that As2O3 therapy induced a progressive decrease in the proportion of cells expressing CD33, an antigen associated with primitive myeloid cells, along with an increase in the proportion of cells expressing CD11b, an antigen restricted to mature myeloid elements. As2O3 also induced the increment of cells that simultaneously expressed both antigens and displayed a hybrid signal of PML and RAR genes on FISH analysis. Interestingly, serial Western blot analysis of BM mononuclear cells during As2O3 treatment showed induced expression of the precursor forms of caspase 2 and caspase 3 and activation of both caspase 1 and caspase 3. (1999) demonstrated that As2O3 induced apoptosis and modest differentiation of APL cells in vivo, and significantly prolonged the survival of the diseased animals. In subcutaneous tumors which were formed by implantation of ATRA resistant UF 1 APL cells into hGM CSF producing transgenic SCID mice (Kinjo et al., 2000), tumor size was decreased to half the initial one after As2O3 treatment, with the appearance of cells showing typical apoptotic morphology. Meanwhile, one of the As2O3 treated mice showed mature granulocytes in the diminished tumor.

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